Endometrial dating histology
The histologic features of what constitutes “normal” endometrium change with a woman’s age, through the premenarchal, reproductive, perimenopausal, and postmenopausal years.During the reproductive years, the cyclical hormonal changes of the menstrual cycle provide a continuously changing morphologic phenotype that is “normal.” In biopsy specimens, the combination of these cyclical changes along with artifacts and limited sampling can make normal patterns difficult to interpret.This study defined a transcriptome characteristic of active cell proliferation in the non-receptive samples with a marked overall down-regulation of this pathway in potentially receptive samples—suggesting a transitional state associated with receptivity but not implantation.
The process triggers an influx of decidual leukocytes along with morphological and functional changes of ESCs.
However, decidualization-like reactions have also been observed in some species that don't display hemochorial placentation.
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